Clinical efficacy and mechanism of total glucosides from white paeony for radioactive liver damage.
10.19540/j.cnki.cjcmm.20170121.040
- Author:
Shi-le GAO
1
;
Zong-Tao HU
1
;
Liu-Yi DONG
2
;
Zhen-le FEI
3
;
Jin-Ke MA
3
;
Ji-Yun LIU
3
Author Information
1. The Third Tumor Section, 105th Hospital of Chinese PLA, Hefei 230031, China.
2. Department of Pharmacology, Anhui Medical University, Hefei 230032, China.
3. Department of Radiotherapy Center, 105th Hospital of Chinese PLA, Hefei 230031, China.
- Publication Type:Journal Article
- Keywords:
TGF-β1;
Xiaochaihu decoction;
mechanisms;
radioactive liver damage;
total glucosides from white paeony
- From:
China Journal of Chinese Materia Medica
2017;42(7):1390-1394
- CountryChina
- Language:Chinese
-
Abstract:
To discuss the effects of total glucosides from white paeony on preventing and treating radioactive liver damage, and explore its possible mechanisms. Thirty-six patients with primary hepatic carcinoma from 105th Hospital of Chinese PLA were treated with 3-dimensional conformal radiotherapy and randomly divided into simple irradiation group, total glucosides from white paeony group, and control group. The levels of AST, ALT, HA, LN, PCⅢ, CIV and TGF-β1 in serum of various groups were determined by using ELISA method. As compared with the simple irradiation group and control group, total glucosides from white paeony could obviously decrease the levels of AST, ALT, HA, LN, PCⅢ, CIV and TGF-β1(P<0.05, P<0.01). The results showed that the total glucosides from white paeony could effectively prevent and treat radioactive liver damage, and its mechanism might be associated with decreasing the levels of TGF-β1, and inhibiting the synthesis of collagen synthesis.
