Overall intestinal permeability of multiple components in lotus leaf by in situ single pass intestinal perfusion models.
10.19540/j.cnki.cjcmm.20170223.006
- Author:
Xiu-Wen YIN
1
;
Cheng-Bo HOU
1
;
Jiang-Peng CHEN
1
;
Meng PAN
1
;
Xue-Lian LI
1
;
Zi-Yu WANG
1
;
Ling DONG
1
Author Information
1. Beijing University of Chinese Medicine, Beijing 100102, China.
- Publication Type:Journal Article
- Keywords:
biopharmaceutics classification system of Chinese materia medica;
lotus leaf;
permeability;
single-pass intestinal perfusion(SPIP)
- From:
China Journal of Chinese Materia Medica
2017;42(8):1525-1531
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the overall intestinal permeability of multiple components in lotus leaves and make clear the interaction in composition absorption process. Rat single-pass intestinal perfusion technique was used, and the results showed that the Peff values of nuciferine, demethylanuciferine, rutin, quercetin, kaempferol from lotus leaf were greater than 0.5×10⁻⁴ cm•s⁻¹. In the biopharmaceutics classification system (BCS) intestinal permeability property, these ingredients were high permeable components, while the hyperin was low permeable component. However, in the multi-component environment of the lotus leaf extract, component permeation was changed. Semi quantitative analysis of the unclear components showed that under the multi-component environment, four in seven components with relatively high contents had a Peff value less than 0.5×10⁻⁴ cm•s⁻¹, indicating these 4 components were of low permeability, while other 3 components were of high permeability. The results could be valuable to make clear the overall intestinal permeability of multiple components in lotus leaf, and lay a foundation for studying the mechanism of the lipid-lowering effect of lotus leaf.
