Review on anxiolytic effect of natural small-molecule phenols.
10.19540/j.cnki.cjcmm.20170222.005
- Author:
Xiao-Hong WANG
1
;
Chan-Xi ZHANG
1
;
Gui-Yun LI
2
;
Jian-Mei HUANG
1
;
Hai-Feng ZHAI
3
Author Information
1. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.
2. Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.
3. National Institute on Drug Dependence, Peking University, Beijing 100191, China.
- Publication Type:Journal Article
- Keywords:
anxiolytic effect;
natural small-molecule phenol;
structure-activity relationship
- From:
China Journal of Chinese Materia Medica
2017;42(8):1557-1565
- CountryChina
- Language:Chinese
-
Abstract:
Phenolic compounds have multiple bioactivities, such as anti-oxidant, anti-tumor, anti-bacterial, and anti-inflammatory activities. Recent literatures have demonstrated that flavonoids have a significant anti-anxiety effect on the central nervous system. In addition, studies showed that flavonoids acted as pro-drugs, which were transformed into smaller phenols through intestinal microflora. The small phenolic metabolites were crucial for the anxiolytic effects of these flavonoids, indicating that natural small-molecule phenols(NSMP) generally have anxiolytic activities. In this paper, the supporting evidences (before June 2016) from SciFinder database have been summarized. Furthermore, NSMPs were classified according to chemical structures; their anxiolytic effects, mechanisms, and the structure-activity relationships were also discussed.
