Sesquiterpenoids of endophytic fungus Cerrena sp. from Pogostemon cablin and their cytotoxic activities.
10.19540/j.cnki.cjcmm.20170224.009
- Author:
Jia-Qian XIE
1
;
Yu-Chan CHEN
2
;
Zhang-Hua SUN
2
;
Hong-Xin LIU
2
;
Sai-Ni LI
2
;
Hao-Hua LI
2
;
Xiao-Xia GAO
1
;
Wei-Min ZHANG
2
Author Information
1. Guangdong Pharmaceutical University, Guangzhou 510006, China.
2. Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China.
- Publication Type:Journal Article
- Keywords:
Cerrena sp.;
Pogostemon cablin;
cytotoxic activity;
endophytic fungus;
sesquiterpenoids
- From:
China Journal of Chinese Materia Medica
2017;42(9):1693-1698
- CountryChina
- Language:Chinese
-
Abstract:
The secondary metabolites of endophytic fungus Cerrena sp.A593 from Pogostemon cablin and their cytotoxic activities were investigated. Eight sesquiterpenoids were isolated from the fermentation broth of the strain A593 by silica gel, reverse phase silica gel, Sephadex LH-20, HPLC and so on. Their structures were identified as chloriolin B(1), chloriolin C(2), pleurocybellone A(3), dihydrohypnophilin(4), cucumin F(5), antrodin A(6), 10α-hydroxyamorphan-4-en-3-one(7), and connatusin A(8). Compounds 1- 8 were firstly found from the genus Cerrena. All isolated sesquiterpenoids were evaluated for in vitro cytotoxic activities against HepG-2, SF-268, MCF-7 and NCI-H460 tumor cell lines. Compounds 1-3 showed inhibitory activities against the four tumor cell lines with IC₅₀ values ranging from 20.33 to 63.13 μmol•L⁻¹.
