Study of the gene expression pattern in the Kkay mouse with type 2 diabetes by genomic-scale gene expression analysis.
- Author:
Qing-hua GUO
1
;
Ju-ming LU
;
Ling YIN
;
Chang-yu PAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Diabetes Mellitus, Experimental; genetics; Diabetes Mellitus, Type 2; genetics; Gene Expression; Gene Expression Profiling; Liver; metabolism; Male; Mice; Mice, Mutant Strains; genetics; Oligonucleotide Array Sequence Analysis; RNA, Messenger; genetics; metabolism
- From: Acta Academiae Medicinae Sinicae 2002;24(5):462-465
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the genes differentially expressed in the liver of Kkay diabetic and normal mice by genomic-scale gene expression analysis.
METHODScDNA microarray chips containing 8,192 cDNAs were used to explore the gene expression pattern of Kkay mouse liver.
RESULTSOne hundred and fifty-four genes were screened out, including 68 complete cDNAs and expressed sequence tags, and among them 40 genes were up-regulated and 114 genes were down-regulated respectively.
CONCLUSIONMost of the gene expression analysis results were consistent with previous study, and the gene expression pattern of Kkay mouse based on cDNA microarray could be used for high-throughout screening out the genes associated with type 2 diabetes.
