Progress in the study on the molecules in CD28 family.
- Author:
Yun-lu FENG
1
;
Li-ping ZHU
;
Wei HE
Author Information
1. Department of 98 Clinical Medicine, PUMC, Beijing 100005, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Antigens, CD;
Antigens, Differentiation;
immunology;
CD28 Antigens;
immunology;
CTLA-4 Antigen;
Humans;
Immunoglobulin Fc Fragments;
immunology;
Signal Transduction
- From:
Acta Academiae Medicinae Sinicae
2002;24(5):536-539
- CountryChina
- Language:Chinese
-
Abstract:
CD28 family consists of CD28, ICOS, CTLA-4 and PD-1 molecules. The former two are activation receptors and the later two are inhibition receptors. They produce co-stimulatory signals combining with the relevant molecules in B7 family, which plays important role in T cell activation and homeostasis among T subsets. Although the mechanism of signaling by CD28 and CTLA-4 has been well studied, many questions still remain to be answered. Further investigations are required for substantiating the dual-signaling model.
