Discovery of MHC restriction in antigen recognition of T cells.
- Author:
Gong-tao LAN
1
;
Li-ping ZHU
;
Wei ZHANG
Author Information
1. Department of Medicine, PUMC, Beijing 100730, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Antigen-Presenting Cells;
immunology;
Epitopes;
immunology;
Humans;
Immunity, Cellular;
Major Histocompatibility Complex;
immunology;
Receptors, Antigen, T-Cell;
immunology;
T-Lymphocytes;
immunology
- From:
Acta Academiae Medicinae Sinicae
2002;24(5):539-541
- CountryChina
- Language:Chinese
-
Abstract:
T cell can only recognize specific antigenic peptide-MHC complex on antigen-presenting cell. This is MHC restriction in antigen recognition of T cell. This phenomenon was discovered by an Austrian scientist Peter. C. Doherty and a Swedish scientist Rolf. M. Zinkernagel by chance. Then, in order to explain the phenomenon, they proposed two hypotheses: dual receptor and modified self. In the during following 20 years numbers of scientists spent great amount of time in the study of the phenomenon. The process of cell-mediated immune response becomes clear, which greatly promotes the advancing of immunology and many related disciplines.
