Telomerase expression in various lesions of adrenal cortex.
- Author:
Quan-zong MAO
1
;
Shi RONG
;
Jin-hai FAN
;
Zhi-gang JI
;
Han-zhong LI
;
Mei-fu ZANG
Author Information
- Publication Type:Journal Article
- MeSH: Adrenal Cortex; enzymology; Adrenal Cortex Neoplasms; enzymology; Adrenocortical Adenoma; enzymology; Biomarkers, Tumor; analysis; Cushing Syndrome; enzymology; Humans; Telomerase; analysis; biosynthesis; genetics
- From: Acta Academiae Medicinae Sinicae 2002;24(2):188-189
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of telomerase in various lesions of adrenal cortex.
METHODSBy autoradiography-based telomeric repeat amplification protocol, telomerase expression was detected in 36 samples of adrenocortical lesions, including 29 cases adrenocortical adenoma (8 Cushing's syndrome, 17 aldosteronism and 4 nonfunctional adenomas), 5 cases of hyperplasia of adrenal cortex (presented with Chushing' syndrome), 2 cases adrenocortical carcinoma, and 4 samples of normal adrenal cortex.
RESULTSOf the 40 samples, 2 cases of adrenocortical carcinomas had telomerase expression, and the others had no telomerase expression detected.
CONCLUSIONSNo significant telomerase expression was found among different endocrine functional benign adrenocortical lesions. Telomerase expression may be used as an important marker of malignant adrenocortical tumor.
