Expression of drug resistance-associated proteins in brain of patients with refractory epilepsy.
- Author:
Wei WANG
1
;
Yue-Shan PIAO
;
Lei LIU
;
Li CHEN
;
Li-Feng WEI
;
Hong YANG
;
De-Hong LU
Author Information
- Publication Type:Journal Article
- MeSH: ATP-Binding Cassette, Sub-Family B, Member 1; analysis; Adolescent; Adult; Brain; metabolism; Brain Neoplasms; chemistry; Child; Drug Resistance, Multiple; Epilepsy; drug therapy; genetics; metabolism; Female; Ganglioglioma; genetics; metabolism; Humans; Male; Malformations of Cortical Development; genetics; metabolism; Multidrug Resistance-Associated Proteins; genetics; metabolism; pharmacology; Tuberous Sclerosis; metabolism; Young Adult
- From: Chinese Journal of Pathology 2008;37(1):21-26
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expression of P-glycoprotein, multi-drug resistance associated protein and major vault protein in pathologic brain specimens, and to investigate their roles in the pathogenesis of refractory epilepsy.
METHODSImmunohistochemical study was performed in pathology specimens from 18 cases of refractory epilepsy (including 5 cases of focal cortical dysplasia, 3 cases of tuberous sclerosis, 5 cases of ganglioglioma and 5 cases of dysembryoplastic neuroepithelial tumor).
RESULTSBoth the P-glycoprotein and major vault protein were localized in microvascular endothelium of the lesions. Major vault protein was also seen in balloon cells and some neuronal cells. On the other hand, multi-drug resistance associated protein was mainly localized in the neuronal component of the lesions. In general, the expression of P-glycoprotein and major vault protein in tumoral tissue was higher than that in non-tumoral tissue. The expression of multi-drug resistance associated protein and major vault protein was also different in the neoplastic glial cells of ganglioglioma and dysembryoplastic neuroepithelial tumor.
CONCLUSIONSP-glycoprotein, multi-drug resistance associated protein and major vault protein contribute to the pathogenesis of refractory epilepsy. They may however have different roles, with different cellular localization.
