Tuberculin Reactivity to 2 TU PPD RT23 Following Intradermal BCG Vaccination in Neonates.
- Author:
Jong Hwa LEE
1
;
Sung Hee OH
Author Information
1. Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Tuberculin response;
BCG;
Tuberculosis;
PPD
- MeSH:
Humans;
Infant;
Infant, Newborn*;
Infant, Premature;
Korea;
Mycobacterium bovis*;
Tuberculin*;
Tuberculosis;
Vaccination*
- From:Journal of the Korean Pediatric Society
2000;43(11):1418-1422
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: 2 TU of PPD HTZ3 has been substituted for 5 TU of PPD RT23 since 1998 in Korea without adequate evaluation. This study was undertaken to evaluate the tuberculin reactivity to 2 TU of PPD RT23 following intradermal BCG vaccination in neonates. The results were compared with the previous report generated with 5 TU of PPD RT23 in 1993. METHODS: Two hundred neonates born from October 1998 to April 1999 in Hanyang University Hospital were vaccinated with O.lmL of BCG(Institute Merieux, France) intradermally and tested for tuberculin response to 2 TU of PPD RT23 three months later. RESULTS: Among the total 200 infants, 31 showed no response on Mantoux test and the remaining 169 infants showed induration in diameter of 7.52.4rnm in bell shaped distribution(155 fullterm infants : 7.7+/-2.3mrn, l4 premature infants :.5.2+/- 2.2mm). When the diameter of induration was equal to or greater than 5 rnm considered for positive tuberculin response, the positive rate of tuberculin response in fullterm infants was 80.7%(146/181 infants) and significantlv greater than 52.6%(9/19 infants) in prernature infants(P=0.0119). CONCLUSION: Tuberculin reactivity to 2 TU of PPD RT23 on infants vaccinated with BCG during neonatal period appears to be lower than that to 5 TU of PPD RT23 reported previously, indicating that a new criteria for tuberculin reactivity to 2 TU of PPD RT23 should be established in future studies.
