TNFR 2 M196R Polymorphism and Acne Vulgaris in Han Chinese: A Case-control Study
10.1007/s11596-010-0366-z
- Author:
TIAN LIMING
1
;
XIE HONGFU
;
YANG TING
;
HU YAOHUA
;
LI JI
;
WANG WEIZHEN
Author Information
1. Department of Dermatology,Xiangya Hospital,Central South University,Changsha 410008,China
- Keywords:
acne vulgaris;
cytokine;
polymorphism;
TNFR2
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2010;30(3):408-411
- CountryChina
- Language:Chinese
-
Abstract:
In this case-control study,the relationship between M196R(676 T→G)variant in exon6 of tumor necrosis factor receptor type 2(TNFR2)gene and genetic susceptibility of ache vulgaris in Han Chinese was investigated.A total of 93 acne vulgaris patients and 90 healthy subjects from Han Chinese ethnic group were enrolled in this study.Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)technique was adopted to analyze the single nucleotide polymorphisms(SNPs)of TNFR2 M 196R gene,and to examine the association between ache vulgaris and the polymorphisms in TNFR2 M196R gene.The relationship between different genotypcs and the susceptibility of acne vulgaris was analyzed.The results showed that there was significant differencein the frequency of the genotype M/R+R/R in the TNFR2 M196R genetic polymorphisms between acne vulgaris patients and healthy controls(X2=4.343; P=0.037; OR=1.899; 95% CI: 1.036-3.445);and there was significant difference in the allele(R)frequency between acne vulgaris patients and healthy controls(X2=5.588; P=0.018; OR=1.838; 95% CI: 1.105-3.057).It was concluded that the high frequency of 196R allele in the functional M196R polymorphism of TNFR2 is a risk factor for acne vulgaris in Han Chinese.
