IL-17 Contributes to Autoimmune Hepatitis
10.1007/s11596-010-0446-0
- Author:
YU HAIJING
1
;
HUANG JIAQUAN
;
LIU YANG
;
AI GUO
;
YAN WEIMING
;
WANG XIAOJING
;
NING QIN
Author Information
1. Department of Infectious Disease,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China
- Keywords:
autoimmune hepatitis;
interleukin-17
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2010;30(4):443-446
- CountryChina
- Language:Chinese
-
Abstract:
The role of interleukin-17 (IL-17) in autoimmune hepatitis (AIH) was investigated. A mouse model of experimental autoimmune hepatitis was established, and the syngeneic S-100 antigen emulsified in complete Freud's adjuvant was injected intraperitoneally into adult male C57BL/6 mice. The IL-17 expression in serum and the livers of the mice models was detected by using ELISA and immunohistochemistry, respectively. IL-17 neutralizing antibody was used to study the biological effect of IL-17 in the experimental AIH. IL-17 neutralizing antibody in vivo administration alleviated the hepatic inflammation and ALT level in the AIH model. IL-17 in the peripheral blood mononuclear cells (PBMC) of A1H patients was measured by using real-time PCR method. The results showed that IL-17 level was significantly up-regulated in AIH patients and mice models. It was concluded that IL-17 contributed to the development of A IH and might be a potential therapeutic target of AIH.
