Dysregulation of E-cadherin in Chronic Rhinosinusitis with Nasal Polyps
10.1007/s11596-010-0459-8
- Author:
KONG WEIJIA
1
;
WU JUNHUA
;
WANG YANJUN
;
YUE JIANXIN
;
ZHANG SONG
;
YU YANPING
Author Information
1. Department of Otorhinolaryngology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China
- Keywords:
E-cadherin;
chronic rhinosinusitis;
nasal polyps
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2010;30(4):509-513
- CountryChina
- Language:Chinese
-
Abstract:
E-cadherin is a key epithelial protein and adhesive molecule.This study detected the E-cadherin expression in patients with chronic rhinosinusitis with nasal polyps(CRSwNP)and controls,and analyzed its possible role in the pathogenesis of CRSwNP.The expression of E-cadherin was detected by using Western blotting and immunohistochemistry in controls and patients with CRSwNP.Computed tomography(CT)scan findings were scored.The results showed that the E-cadherin expression was up-regulated in patients with CRSwNP as compared with controls(P=0.039)and the positive staining was predominantly localized on the epithelial cell membrane.E-cadherin level was correlated negatively with Lund-Mackay scores in patients with CRSwNP(r=-0.604,P=-0.005).It is suggested that E-cadherin may be involved in the pathogenesis of CRSwNP and correlated with disease severity.
