Analysis of P53 Mutation and Invasion Front Grading in Oral Squamous Cell Carcinomas
10.1007/s11596-010-0462-0
- Author:
TANG SANBAO
1
;
XU DONGXUAN
;
ZHOU BIN
Author Information
1. Department of Endodontics,Hospital of Stomatology,Wuhan University,Wuhan 430079,China
- Keywords:
oral squamous cell carcinomas;
P53 mutation;
invasion front grading
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2010;30(4):525-529
- CountryChina
- Language:Chinese
-
Abstract:
We examined P53 mutation and invasion front grading(IFG)in 30 cases of oral squamous cell carcinomas(OSCCs).The association of P53 mutation and IFG scores with clinicopathological parameters was evaluated.P53 mutation existed in exon 5-8 in 15 out of the 30 OSCCs(50%).The incidence of P53 mutation was not associated with age,gender,N value and TNM stage.However,there was a significant correlation between P53 mutation and T value(P=-0.046).There were no statistically significant correlations among the clinicopathological parameters and IFG.Interestingly,The IFG score in OSCCs with P53 mutation was significantly higher than that in OSCCs without P53 mutation(P<0.001).These results suggest that the high incidence of P53 mutation is a major mechanism of OSCC carcinogenesis.The presence of P53 mutation indicates the most anaplastic fields in the invasive areas of the tumors,which may predict poor prognosis for the patients.
