Acute hyperammonemic encephalopathy after 5-fluorouracil based chemotherapy.
10.4174/astr.2016.90.3.179
- Author:
Hee Jung YI
1
;
Kyung Sook HONG
;
Nara MOON
;
Soon Sup CHUNG
;
Ryung Ah LEE
;
Kwang Ho KIM
Author Information
1. Department of Surgery, Ewha Womans University School of Medicine, Seoul, Korea. eastgate@ewha.ac.kr
- Publication Type:Case Report
- Keywords:
Colorectal neoplasma;
5-Fluorouracil;
Hyperammonemia;
Metabolic brain diseases
- MeSH:
Ammonia;
Brain Diseases, Metabolic;
Central Nervous System;
Chemotherapy, Adjuvant;
Colonic Neoplasms;
Drug Therapy*;
Fluorouracil*;
Humans;
Hyperammonemia;
Leucovorin;
Neutropenia;
Thrombocytopenia
- From:Annals of Surgical Treatment and Research
2016;90(3):179-182
- CountryRepublic of Korea
- Language:English
-
Abstract:
5-Fluorouracil (5-FU) based chemotherapy has been commonly used to treat metastatic or advanced colon cancer as an adjuvant chemotherapy. Although the side effects of 5-FU such as gastrointestinal problems and neutropenia and thrombocytopenia are common, not many cases of 5-FU related encephalopathy are reported. Hyperammonemic encephalopathy is a rare central nervous system toxicity following 5-FU chemotherapy manifesting as altered mental status with elevated ammonia levels with no radiologic abnormality. We report one case of 5-FU induced hyperammonemic encephalopathy occurring after Folfox4 (oxaliplatin, folinic acid and 5-fluorouracil) chemotherapy in a colon cancer patient who presented with confused mental status soon after the chemotherapy and review the 5-FU related encephalopathy.
