Associations of HLA gene with leukemia in 1186 cases.
10.7534/j.issn.1009-2137.2014.02.001
- Author:
Xiao-Jing WANG
1
;
Yi-Zhi ZHANG
1
;
Hai-Yan SUN
1
;
Qing-Hua LI
1
;
Kun RU
2
Author Information
1. Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Scinces & Peking Union Medical College, Tianjin 300020, China.
2. Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Scinces & Peking Union Medical College, Tianjin 300020, China. E-mail: kunru@yahoo.com.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Case-Control Studies;
Child;
Child, Preschool;
HLA-A Antigens;
genetics;
HLA-B Antigens;
genetics;
HLA-DRB1 Chains;
genetics;
Histocompatibility Testing;
Humans;
Infant;
Leukemia;
genetics;
immunology;
therapy;
Major Histocompatibility Complex;
genetics;
Middle Aged;
Retrospective Studies;
Tumor Escape;
Young Adult
- From:
Journal of Experimental Hematology
2014;22(2):263-268
- CountryChina
- Language:Chinese
-
Abstract:
The purpose of this study was to evaluate the potential associations between HLA-A, B, DRB1 gene and leukemia. A total of 1186 leukemic patients, including 326 patients with acute lymphoblastic leukemia (ALL), 545 patients with acute myeloid leukemia (AML), 315 patients with chronic myeloid leukemia (CML), and 1234 healthy unrelated donors were typed and were compared in a single centre by using same technique, then the Bonferroni correction method was used to correct the Type I error. The results indicated that as compared with the control,the frequency of HLA-DRB1(*)09 in ALL group significantly decreased (10.87% versus 16.08%; Pc = 0.014, OR = 0.637, 95% CI = 0.487-0.834), while in comparison with control, the frequency of HLA-B(*)18 in CML group was significantly higher (1.28% vs 0.20%; Pc = 0.039, OR = 6.336, 95% CI = 2.066-19.434). The positive and negative relation may exist between certain HLA molecules and leukemia. The negative relation between HLA-DRB1(*)09 and ALL indicated that DRB1*09 might play an important role by a restricted T-cell immune response in the early leukemogenic events, whereas the positive relation between HLA-B(*)18 and CML suggests that the B(*)18 molecules may not actively present leukemia-specific antigens resulting in immune escape. It is concluded that these findings can contribute to developing more appropriate method in leukemic immunotherapy.
