Metabolic syndrome is associated with better prognosis in patients with tongue squamous cell carcinoma.

Lan Zou; Tian-run Liu; An-kui Yang

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Metabolic syndrome is associated with better prognosis in patients with tongue squamous cell carcinoma.

Author: Lan ZOU ^{1
,

2
,

3} ; Tian-Run LIU ⁴ ; An-Kui YANG ¹ ;
Author Information

1. Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center
2. State Key Laboratory of Oncology in South China
3. Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, 510060, P. R. China. zlyyzl@foxmail.com.
4. Department of Otorhinolaryngology Head and Neck Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510655, P. R. China. dortianr@163.com.
Publication Type:Journal Article
MeSH: Carcinoma, Squamous Cell; Humans; Kaplan-Meier Estimate; Metabolic Syndrome; Mortality; Prognosis; Retrospective Studies; Tongue Neoplasms
From:Chinese Journal of Cancer 2015;34(4):184-188
CountryChina
Language:English
Abstract:
INTRODUCTIONMetabolic syndrome (MS) is associated with several cancers, but it is not clear whether MS affects the prognosis of tongue squamous cell carcinoma (TSCC). This study aimed to evaluate the prognostic value of MS in TSCC.
METHODSClinical data from 252 patients with TSCC who were initially treated at the Sun Yat-sen University Cancer Center between April 1998 and June 2011 were collected, and the associations between MS and clinicopathologic factors were retrospectively analyzed. Prognostic outcomes were examined by Kaplan-Meier analysis and Cox regression analysis.
RESULTSOf the 252 patients, 48 were diagnosed with MS. MS was associated with early N category in TSCC (P < 0.001). The patients with MS showed longer survival than those without MS (P = 0.028). MS was an independent prognostic factor for patients with TSCC.
CONCLUSIONSMS is associated with early N category in TSCC. It is an independent prognostic factor for better survival in patients with TSCC.