Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins.
10.1186/s40880-015-0030-x
- Author:
Meiqi ZENG
1
;
Manyin ZHENG
2
;
Desheng LU
3
;
Jun WANG
4
;
Wenqi JIANG
5
;
Ou SHA
6
Author Information
1. School of Medicine, Shenzhen University Health Science Center, Shenzhen, 518060, Guangdong, People's Republic of China. 2140220106@email.szu.edu.cn.
2. School of Medicine, Shenzhen University Health Science Center, Shenzhen, 518060, Guangdong, People's Republic of China. 83484191@qq.com.
3. School of Medicine, Shenzhen University Health Science Center, Shenzhen, 518060, Guangdong, People's Republic of China. delu@szu.edu.cn.
4. School of Medicine, Shenzhen University Health Science Center, Shenzhen, 518060, Guangdong, People's Republic of China. yxywj@szu.edu.cn.
5. School of Medicine, Shenzhen University Health Science Center, Shenzhen, 518060, Guangdong, People's Republic of China. jiangwq@sysucc.org.cn.
6. School of Medicine, Shenzhen University Health Science Center, Shenzhen, 518060, Guangdong, People's Republic of China. shaou@szu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Animals;
Antineoplastic Agents;
Apoptosis;
Endoplasmic Reticulum;
Humans;
Mitochondria;
Plant Proteins;
Receptors, Death Domain;
Ribosome Inactivating Proteins;
Ribosomes
- From:Chinese Journal of Cancer
2015;34(8):325-334
- CountryChina
- Language:English
-
Abstract:
Ribosome-inactivating proteins (RIPs) belong to a family of enzymes that attack eukaryotic ribosomes and potently inhibit cellular protein synthesis. RIPs possess several biomedical properties, including anti-viral and anti-tumor activities. Multiple RIPs are known to inhibit tumor cell proliferation through inducing apoptosis in a variety of cancers, such as breast cancer, leukemia/lymphoma, and hepatoma. This review focuses on the anti-tumor activities of RIPs and their apoptotic effects through three closely related pathways: mitochondrial, death receptor, and endoplasmic reticulum pathways.
