Wnt3a: functions and implications in cancer.
10.1186/s40880-015-0052-4
- Author:
Sha HE
1
;
Yi LU
2
;
Xia LIU
3
;
Xin HUANG
4
;
Evan T KELLER
5
;
Chao-Nan QIAN
6
;
Jian ZHANG
7
Author Information
1. Key Laboratory of Longevity and Ageing-related Diseases, Ministry of Education, Nanning, Guangxi, 530021, P.R. China. 514239052@qq.com.
2. Key Laboratory of Longevity and Ageing-related Diseases, Ministry of Education, Nanning, Guangxi, 530021, P.R. China. luyi5555@hotmail.com.
3. Key Laboratory of Longevity and Ageing-related Diseases, Ministry of Education, Nanning, Guangxi, 530021, P.R. China. realliuxia@sina.com.
4. Key Laboratory of Longevity and Ageing-related Diseases, Ministry of Education, Nanning, Guangxi, 530021, P.R. China. xin.huang2005@gmail.com.
5. Department of Urology and Pathology, School of Medicine, University of Michigan, Ann Arbor, MI, 48109, USA. etkeller@umich.edu.
6. Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong, 51006, P.R. China. qianchn@sysucc.org.cn.
7. Key Laboratory of Longevity and Ageing-related Diseases, Ministry of Education, Nanning, Guangxi, 530021, P.R. China. jianzhang008@hotmail.com.
- Publication Type:Journal Article
- MeSH:
Cell Division;
physiology;
Gene Expression Regulation, Neoplastic;
physiology;
Humans;
Neoplasm Proteins;
metabolism;
physiology;
Neoplasms;
genetics;
metabolism;
pathology;
Tumor Cells, Cultured;
Wnt Signaling Pathway;
physiology;
Wnt3A Protein;
metabolism;
physiology
- From:Chinese Journal of Cancer
2015;34(12):554-562
- CountryChina
- Language:English
-
Abstract:
Wnt3a, one of Wnt family members, plays key roles in regulating pleiotropic cellular functions, including self-renewal, proliferation, differentiation, and motility. Accumulating evidence has suggested that Wnt3a promotes or suppresses tumor progression via the canonical Wnt signaling pathway depending on cancer type. In addition, the roles of Wnt3a signaling can be inhibited by multiple proteins or chemicals. Herein, we summarize the latest findings on Wnt3a as an important therapeutic target in cancer.
