Cytogenetic analysis on patients with a history of spontaneous abortion
- Author:
Mei-Yu YU
1
;
Yu-Lan CHEN
;
Jian QIU
Author Information
1. The Affiliated Obstetrics and Gynecology Hospital, College of Medical Sciences, Zhejiang University, Hangzhou 310006, China.
- Publication Type:Journal Article
- From:
Journal of Zhejiang University. Medical sciences
2002;31(5):375-378
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the incidence and identify the type of chromosome abnormalities in couples with spontaneous abortion. Also to observe the effect of balanced translocation on pregnancy outcome. METHODS: A total of 9258 cases of spontaneous abortion were studied. Lymphocyte culture and harvest were performed according to standard methods. Karyotypes were analyzed by G-banding in all cases and C- or N-banding in some cases in additions. RESULTS: The overall incidence of chromosomal abnormalities was 2.72% (women 3.32%, men 2.12%). In womem with 4 or more spontaneous abortions, the incidence of chromosomal abnormalities was significantly higher (4.9%, P<0.01). Among the 252 cases the following chromosome abnormalities were noted: translocations (81.0%), numerical abnormalities (13.1%), inversions (4.0%), deletion (0.4%) and marker chromosomes (0.8%). There were 473 pregnancies in 130 carriers of balanced translocations; their spontaneous abortions rate was 90.1%. CONCLUSION: Womem with a history of spontaneous abortion have a higher rate of chromosomal abnormalities than their male partner. Chromosomal abnormalities are significantly more common in women with 4 or more spontaneous abortions. Balanced translocations are the major abnormal karyotpes associated with spontaneous abortions. In such patients, prenatal diagnostic testing is advised for all subsequent pregnancies.
