Alteration of the content of minor elements in apoptotic cells induced by anti-cancer drugs with synchronous radiation
- Author:
Li-Rong CHEN
1
;
Shu ZHENG
;
Yu-Fa CHEN
;
Su-Zhan ZHANG
;
Yu-Ying HUANG
Author Information
1. Cancer Institute, College of Medical Sciences, Zhejiang University, Hangzhou 310009, China.
- Publication Type:Journal Article
- From:
Journal of Zhejiang University. Medical sciences
2002;31(4):265-268
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To explore the change of content of minor elements and its biological implication in apoptotic processes. METHODS: The content of minor elements of apoptotic cells from breast cancer induced by anti-cancer drugs was quantitatively analysed with synchronous radiation X-ray fluorescence. RESULTS: Seven kinds of minor elements including Ti, Cr, Fe, Cu, Zn, Ga and Ge as well as five major elements P, S, Ca, Cl and K were detected in the apoptotic and control cells. The content of elements Zn and P in apoptotic cells after 48 h treatment with taxol and colchicine was significantly increased higher than that in the control cells P<0.05). The content of element Fe in 48 h treatment with taxol was significantly decreased lower than that in the control cells P<0.05). The same trend of change of elements was observed during the process of apoptotic cells death induced with VP-16 or cycloheximide. CONCLUSION: This results suggest that the elements Zn, Fe and P should be involved in apoptosis induced by anti-cancer drugs.
