A study of the progression of cirrhosis in patients with human immunodeficiency virus and hepatitis C virus coinfection.
- Author:
Yong-Hong ZHANG
1
;
Xin-Yue CHEN
;
Hao WU
;
Shi-Qi DIAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; CD4-CD8 Ratio; China; epidemiology; Female; HIV Infections; complications; immunology; HIV-1; Hepatitis C; complications; immunology; Humans; Liver Cirrhosis; complications; epidemiology; Male; Middle Aged; Retrospective Studies
- From: Chinese Journal of Hepatology 2005;13(4):264-266
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVESTo study the progression of cirrhosis in patients with HIV/HCV coinfection.
METHODSThe patients were divided into two groups, HIV/HCV coinfection group (n = 140) and simple HCV infection group (n = 33). A retrospective study was designed to compare the development of cirrhosis in a 15-year period between the two groups.
RESULTSThe development of cirrhosis in the HIV/HCV coinfection group was higher than that in the simple HCV infection group (16.4% vs. 3.0%, P=0.045). Counts of CD4+ T and CD8+ T in the HIV/HCV group were 200.0+/-134.1 cells/microl and 880.6+/-444.2 cells/microl, respectively. The counts of CD4+ T and CD8+ T in the group of simple HCV infection were 752.3+/-251.7 cells/microl and 529.0+/-170.7 cells/microl, respectively. There were significant differences between the two groups regarding the counts of CD4+ T and CD8+ T. Comparing the cases of HCV RNA (+) and anti-HCV (+) with the cases of HCV RNA (+) and anti-HCV (-), we found that the ratio was 89 to 15 in the group of HIV/HCV coinfection, and 25 to 0 in the group of simple HCV infection. The difference between the two groups was statistically significant (P = 0.043).
CONCLUSIONHIV/HCV coinfection can accelerate the progression of cirrhosis, which may be due to the effect of HIV on cellular immunity and humoral immunity.
