Noninvasive prenatal diagnosis of single gene disorders through cell-free fetal DNA in maternal blood.
- Author:
Qi-wei GUO
1
;
Yu-lin ZHOU
Author Information
1. Molecular Diagnostic Laboratory, Center for Prenatal Diagnosis, Maternal and Children's Health Hospital of Xiamen, Xiamen, Fujian, 361003 P.R. China.
- Publication Type:Journal Article
- MeSH:
DNA;
blood;
genetics;
Female;
Fetal Diseases;
diagnosis;
genetics;
Genetic Diseases, Inborn;
diagnosis;
genetics;
Humans;
Maternal-Fetal Exchange;
Pregnancy;
Prenatal Diagnosis;
methods
- From:
Chinese Journal of Medical Genetics
2009;26(4):410-413
- CountryChina
- Language:Chinese
-
Abstract:
The discovery of cell-free fetal DNA (cff-DNA) in maternal plasma offered a new way to noninvasive prenatal diagnosis for single gene disorders. In the past decade, many techniques such as real-time PCR, pyrophosphorolysis-activated polymerization, mass spectrum and digital PCR have been developed for noninvasive prenatal diagnosis. In this review, the author discuss the principles, applications, advantages and disadvantages of these techniques.
