Trisomy 8 in chronic lymphocytic leukemia.
- Author:
Xin CAO
1
;
Wei XU
;
Qiong LIU
;
Dan-xia ZHU
;
Chun QIAO
;
Yu-jie WU
;
Hong-xia QIU
;
Jian-yong LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Chromosomes, Human, Pair 8; genetics; Humans; Karyotyping; Leukemia, Lymphocytic, Chronic, B-Cell; diagnosis; genetics; Male; Middle Aged; Prognosis; Trisomy
- From: Chinese Journal of Medical Genetics 2009;26(4):443-445
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the incidence of trisomy 8 in chronic lymphocytic leukemia (CLL) and its significance in prognosis.
METHODSA panel of probes and fluorescence in situ hybridization (FISH) were used to detect trisomy 8 in 151 CLL patients combined with chromosome karyotype analysis.
RESULTSThere were 2 patients (1.3%) with trisomy 8 in the 151 CLL patients, and the number of trisomy 8 cells was 8% and 10% respectively. The karyotypes were 47,XY,+8[2]/49,XY,+14,+20,+21[2]/ 46,XY[16], and 47,XX,+8[2]/46,XX[18], respectively.
CONCLUSIONTrisomy 8 was rare in CLL, and its significance in prognosis of CLL still remains unknown.
