Association between the regulator of G-protein signaling 2 gene 1891-1892del TC polymorphism with hypertension in Xinjiang Kazakh population.
- Author:
Juhong ZHANG
1
;
Nanfang LI
;
Zhitao YAN
;
Yanying GUO
;
Ling ZHOU
;
Hongmei WANG
;
Jin YANG
;
Wenli LUO
;
Jianhang CHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Asian Continental Ancestry Group; ethnology; genetics; Blood Pressure; Case-Control Studies; China; Female; Genetic Predisposition to Disease; Humans; Hypertension; blood; ethnology; genetics; physiopathology; Male; Middle Aged; Polymorphism, Genetic; RGS Proteins; genetics; Risk Factors; Uric Acid; blood
- From: Chinese Journal of Medical Genetics 2010;27(1):29-33
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of the 1891-1892del TC polymorphism of regulator of G-protein signalling 2 (RGS2) gene with hypertension in Xinjiang Kazakh population.
METHODSThe case-control study was performed in 444 cases and 489 controls. The genotypes of the individuals in the 1891-1892del TC locus were identified by TaqMan method.
RESULTSA significant association was observed between the1891-1892TC insertion/deletion polymorphism with hypertension in men (OR=1.698, P=0.03) and in the total population (OR=1.32, P=0.044). The mean systolic blood pressure and serum uric acid levels of the ID+DD carriers were significantly higher than that of the II carriers (adjusted, P=0.04 and P<0.01).
CONCLUSIONThe results suggest that the D allele of the 1891-1892TC insertion/deletion locus of the RGS2 gene might be an independent risk factor for hypertension in Xinjiang Kazakhs; and the polymorphism may have some influence on serum uric acid level in this population.
