P53 abnormality and clinical prognosis of leukemia patients with complex chromosomal abnormalities.
- VernacularTitle:复杂核型白血病患者的p53基因异常及临床意义
- Author:
Zhaoling ZOU
1
;
Xiangshan CAO
;
Zhilin WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Bone Marrow Cells; cytology; Cells, Cultured; Chromosome Aberrations; Female; Gene Deletion; Humans; In Situ Hybridization, Fluorescence; Leukemia; diagnosis; genetics; mortality; Male; Middle Aged; Prognosis; Survival Analysis; Tumor Suppressor Protein p53; genetics; metabolism; Young Adult
- From: Chinese Journal of Medical Genetics 2010;27(1):81-85
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the p53 deletion in leukemia patients with complex chromosomal abnormalities (CCA) and the clinical significance.
METHODSThe p53 deletion status of 38 leukemia cases with CCA and 24 cases without CCA were analyzed by interphase fluorescence in situ hybridization (I-FISH).
RESULTSThe frequency of p53 deletion in the 38 patients with CCA (44.74%) was significantly higher than that in the 24 cases without CCA (4.16%) (P<0.01). The rate of complete remission in 13 cases of acute leukemia with CCA was 15.4%, with median survival time (MST) of 105 days.
CONCLUSIONI-FISH is a rapid, accurate and sensitive technique for detection of p53 deletion, patients with CCA have a higher p53 deletion and a lower complete remission rate and MST.
