Identification of a new human leukocyte antigen A allele, HLA-A*3020.
- VernacularTitle:人类白细胞抗原新等位基因HLA-A*3020的鉴定及确认
- Author:
Xiaofeng LI
1
;
Xu ZHANG
;
Yang CHEN
;
Kunlian ZHANG
;
Xianzhi LIU
;
Jianping LI
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Base Sequence; HLA-A Antigens; chemistry; genetics; Humans; Molecular Sequence Data; Sequence Alignment; Sequence Analysis, DNA
- From: Chinese Journal of Medical Genetics 2010;27(1):96-99
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo identify a novel human leukocyte antigen (HLA) A allele.
METHODSA new HLA-A allele was found during routine HLA genotyping by polymerase chain reaction-sequence specific oligonucleotide probes (PCR-SSOP) and sequencing-based typing (SBT).
RESULTSThe novel HLA-A*30 allele was identical to A*300101 except that a nucleotide C at position 294 of exon 2 is substituted by A, resulting in codon 98 changed from GAC (D) to GAA (E).
CONCLUSIONA new HLA allele, HLA-A*3020, was identified, and was named officially by the WHO Nomenclature Committee.
