Association of rs2298212 polymorphism in OX40 gene with coronary atherosclerotic disease in Chinese Han population.
- VernacularTitle:OX40基因rs2298212位点与汉族人群冠状动脉粥样硬化疾病的关联研究
- Author:
Guang-hui CHENG
1
;
Hui WANG
;
Long MA
;
Kai ZHANG
;
Li LI
;
Yao-qin GONG
;
Qi-ji LIU
Author Information
- Publication Type:Journal Article
- MeSH: Asian Continental Ancestry Group; ethnology; genetics; Base Sequence; Coronary Artery Disease; genetics; Ethnic Groups; genetics; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Receptors, OX40; genetics
- From: Chinese Journal of Medical Genetics 2010;27(2):171-175
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the association of the OX40 gene rs2298212G/A polymorphism with coronary atherosclerotic disease (CAD) in Chinese Han population.
METHODSFive hundred and thirty six CAD patients and 544 age and ethnic matched controls of Chinese Han population were recruited from Qilu Hospital, Shandong University. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to genotype the selected single nucleotide polymorphism. Distributions of genotypic and allelic frequencies were analyzed by Chi-square test.
RESULTSThe distribution of genotypic and allelic frequencies have no significant differences between the CAD cases and controls(P> 0.05), even after adjusting for age, gender, body mass index, systolic blood pressure, diastolic blood pressure, glucose, total cholesterol, and triglyceride. However, when substratification analysis of the involved coronary artery vessels was performed, significant difference was found between single-vessel and triple-vessel (P= 0.02, OR = 1.56, 95% CI: 1.08-2.26) involvement.
CONCLUSIONThe rs2298212G/A polymorphism in OX40 gene may be associated with the severity of coronary atherosclerotic disease.
