Association of the ALOX5AP gene SG13S114 A/T polymorphism with atherosclerosis.
- Author:
Ying-lei HE
1
;
Xiao-ping JIN
;
Min ZHU
;
Xian-fang LIN
;
Zong-lin XIE
;
Qiu-yue CHEN
Author Information
- Publication Type:Journal Article
- MeSH: 5-Lipoxygenase-Activating Proteins; Aged; Aged, 80 and over; Carotid Artery Diseases; genetics; Carrier Proteins; genetics; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Membrane Proteins; genetics; Middle Aged; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide
- From: Chinese Journal of Medical Genetics 2010;27(2):186-189
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between the polymorphism of SG13S114 A/T in the 5-lipoxygenase-activating protein (ALOX5AP) gene and the stability of carotid atherosclerosis.
METHODSPolymorphism of SG13S114 A/T in the ALOX5AP gene was analyzed in 152 cases of acute infarction with stable plaque, and 132 cases of acute infarction with vulnerable plaques, by using polymerase chain reaction and restriction fragment length polymorphism. Carotid artery plaque was analyzed by carotid artery color ultrasound.
RESULTSThe frequencies of SG13S114 AA genotype and the A allele in the vulnerable plaque group were higher than that in the stable plaque group (P< 0.01).
CONCLUSIONThe polymorphism of SG13S114 A/T in the ALOX5AP gene may be associated with the instability of atherosclerosis. And the SG13S114 A allele may be a risk factor of vulnerable plaques.
