Analysis of the HLA-DPA1 and HLA-DPB1 polymorphism of Zhejiang Han population by PCR-sequence based typing.
- VernacularTitle:浙江汉族人群HLA-DPA1和-DPB1基因多态性分析
- Author:
Wei-jian DAI
1
;
Fa-ming ZHU
;
Li-xing YAN
;
Hong-can ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Asian Continental Ancestry Group; ethnology; genetics; China; ethnology; Databases, Genetic; Ethnic Groups; genetics; Female; Gene Frequency; Genetic Loci; genetics; HLA-DP Antigens; genetics; HLA-DP alpha-Chains; HLA-DP beta-Chains; Haplotypes; Humans; Linkage Disequilibrium; Male; Polymerase Chain Reaction; Polymorphism, Genetic
- From: Chinese Journal of Medical Genetics 2010;27(2):217-220
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the polymorphisms of HLA-DPA1 and HLA-DPB1 loci of Han population in Zhejiang province of China.
METHODSThe alleles of HLA-DPA1 and HLA-DPB1 loci in 100 unrelated healthy individuals were analyzed using polymerase chain reaction-sequence based typing.
RESULTSEight HLA-DPA1 alleles and 19 HLA-DPB1 alleles were found in the population. The HLA-DPA1 alleles with higher frequencies were DPA1*020202 (47.0%), DPA1*010301 (38.5%) and DPA1*020101(10.5%). The HLA-DPB1 alleles with higher frequencies were DPB1*0501, DPB1*020102 and DPB1*040101. The frequencies were 39.5%, 13.5% and 13.0%, respectively. A total of 44 estimated DPA1-DPB1 haplotypes were detected. The HLA-DPA1*020202-DPB1*0501(29.5%) was the most frequent haplotype.
CONCLUSIONThe polymorphism data of the HLA-DPA1 and -DPB1 were obtained in Han population in Zhejiang province of China. There was linkage disequilibrium between the two loci.
