Association of cyclic adenosine monophosphate response element-binding protein gene and major depressive disorder.
- Author:
Xiao-hua LIU
1
;
Yi-feng XU
;
Dong-hong CUI
;
San-duo JIANG
;
Yi-ping QIAN
;
Shun-ying YU
;
Kai-da JIANG
Author Information
- Publication Type:Journal Article
- MeSH: Cyclic AMP Response Element-Binding Protein; genetics; Depressive Disorder, Major; genetics; Female; Genetic Predisposition to Disease; Haplotypes; Humans; Male; Polymorphism, Single Nucleotide; genetics
- From: Chinese Journal of Medical Genetics 2010;27(3):263-266
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between single nucleotide polymorphisms (SNPs) in cyclic adenosine monophosphate response element-binding protein(CREB1) gene and major depressive disorder (MDD).
METHODSWe recruited 105 parent-offspring trios of Chinese descent, extracted whole blood genomic DNA, and genotyped the SNPs in rs10932201 and rs6740584 loci. Single-marker transmission disequilibrium test (TDT), pairwise SNP linkage disequilibrium(LD) and haplotype-based TDT were performed.
RESULTSNo significant association with MDD was observed for SNPs rs10932201 and rs6740584 (P=0.1004 and P=0.4986). However, there was strong positive association between the rs10932201-rs6740584 haplotype and MDD (P=0.00003241), and both haplotypes of A-C and A-T were significantly associated with MDD (P=0.020 and P=0.00022).
CONCLUSIONThe rs10932201-rs6740584 haplotype of the CREB1 gene may play an important role in the pathogenesis of MDD.
