Y chromosome variations and male infertility.
10.3760/cma.j.issn.1003-9406.2010.0.009
- Author:
Yuan YANG
1
;
Si-zhong ZHANG
Author Information
1. Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 PR China.
- Publication Type:Journal Article
- MeSH:
Chromosomes, Human, Y;
genetics;
Haplotypes;
genetics;
Humans;
Infertility, Male;
genetics;
Male;
Mutation;
Spermatogenesis;
genetics
- From:
Chinese Journal of Medical Genetics
2010;27(3):276-281
- CountryChina
- Language:Chinese
-
Abstract:
Male infertility is a common complex disease. Y-linked spermatogenic failure is an important cause for this disorder. Due to the presence of many repeat sequences and the frequent occurrence of non-allelic homologous recombination between the sequences in the male-specific region of the Y (MSY) region of the chromosome, Y chromosome possesses high variation rate. The variations may result in the dosage changes of spermatogenesis-related gene families and lead to male infertility. The present article reviews the recent progress of the study on Y chromosome variations, and its possible effect on spermatogenic function, in DNA level.
