Rapid analysis of metronidazole tablets by optic-fiber sensing technologies and the similarity of ultraviolet spectra.
- Author:
Lu JIN
1
;
Li LI
;
Xin-xia LI
;
Ting YANG
;
Bin KONG
;
Ping-ping XU
Author Information
1. School of Pharmacy, Xinjiang Medical University, Urumqi 830011, China.
- Publication Type:Journal Article
- MeSH:
Chemistry, Pharmaceutical;
Drug Contamination;
Fiber Optic Technology;
methods;
Metronidazole;
administration & dosage;
analysis;
Optical Fibers;
Solubility;
Spectrophotometry, Ultraviolet;
methods;
Tablets
- From:
Acta Pharmaceutica Sinica
2011;46(2):203-206
- CountryChina
- Language:Chinese
-
Abstract:
The paper is to report the development of an optic-fiber sensing technology method to analyze metronidazole tablets rapidly. In this fiber-optic sensing system, the light from source delivering to probe can be dipped into simple-handling sample solution, absorbed by the solution and reflected to the fiber-optic and detected in the detection system at last. Then the drug content can be shown in the screen from the ultraviolet absorption spectra and the consistency between that obtained by this method and that in China Pharmacopoeia can be compared. With regard to data processing, a new method is explored to identify the authenticity of drugs using the similarity between the sample map and the standard pattern by full ultraviolet spectrum. The results indicate that ultraviolet spectra of tablets can be obtained from this technology and the determination results showed no significant difference as compared with the method in China Pharmacopoeia (P > 0.05), and the similarity can be a parameter to identify the authenticity of drugs.
