Existing problems and strategies in liposome-mediated nucleic acid delivery.
- Author:
Ying-Ying ZHANG
1
;
Jian-Ming CHEN
Author Information
1. Department of Pharmaceutical Science, Second Military Medical University, Shanghai 200433, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Humans;
Liposomes;
chemistry;
pharmacokinetics;
Mononuclear Phagocyte System;
metabolism;
Nanoparticles;
Nucleic Acids;
chemistry;
pharmacokinetics;
Photochemical Processes;
Polyethylene Glycols;
chemistry;
pharmacokinetics;
Polymers;
chemistry
- From:
Acta Pharmaceutica Sinica
2011;46(3):261-268
- CountryChina
- Language:Chinese
-
Abstract:
Liposome-mediated nucleic acid delivery has been a focus recently, but in the course of delivering nucleic acid, some hurdles seriously limit the nucleic acid exerting treatment effect. This review refers to a series of problems such as low blood stability, reticuloendothelial system absorption, the lower targeting of liposome and the restriction of endosomal escape which are suffered in liposome-mediated nucleic acid delivery; and gives a detail introduction of strategies such as PEGylation, ligand modification, photochemical internalization, the application of degradation liposome and membrane-lytic peptide, to overcome those problems.
