Synthesis of ferulic acid derivatives and their inhibitory effect on platelet aggregation.
- Author:
Jia-Ming LI
1
;
Yong-Hai ZHAO
;
Guo-Chen ZHONG
;
Zi-Jiang LONG
;
Peng ZHOU
;
Ming YUAN
Author Information
1. Anhui Key Laboratory of Traditional Chinese Medicine, School of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei 230031, China. lijiaming2004@sina.com
- Publication Type:Journal Article
- MeSH:
Animals;
Coumaric Acids;
chemical synthesis;
chemistry;
pharmacology;
Male;
Platelet Aggregation;
drug effects;
Platelet Aggregation Inhibitors;
chemical synthesis;
chemistry;
pharmacology;
Rabbits;
Random Allocation;
Structure-Activity Relationship
- From:
Acta Pharmaceutica Sinica
2011;46(3):305-310
- CountryChina
- Language:Chinese
-
Abstract:
Ferulic acid, an useful compound of Chinese traditional medicine, was used as leading compound. Six ferulic acid derivatives were designed and synthesized based on bioisosterism. Their structures were characterized by IR, 1H NMR, 13C NMR and mass spectra. In vivo experiment showed that ferulic acid derivatives had good inhibitory effects on adenosine diphosphate (ADP) induced platelet aggregation, which were significantly higher than that of Ozagrel.
