The transporters of intestinal tract and their study methods.
- Author:
Zhi-hao LIU
1
;
Ke-xin LIU
Author Information
1. Department of Clinical Pharmacology, College ofPharmacy, Dalian Medical University, Dalian 116044, China.
- Publication Type:Journal Article
- MeSH:
ATP-Binding Cassette Transporters;
administration & dosage;
metabolism;
Animals;
Anion Transport Proteins;
administration & dosage;
metabolism;
Biological Availability;
Humans;
Intestinal Absorption;
Membrane Transport Proteins;
administration & dosage;
metabolism;
Peptide Transporter 1;
Symporters;
administration & dosage;
metabolism
- From:
Acta Pharmaceutica Sinica
2011;46(4):370-376
- CountryChina
- Language:Chinese
-
Abstract:
The absorption of oral drug in the intestine is an important factor to determine the drug bioavailability. There are many intestinal transporters mediating drug absorption, distribution, excretion and drug-drug interaction. Understanding the transport mechanism can improve the effectiveness and safety of drug and guide clinical rational use of drugs. The in vivo and in vitro methods are used to predict the transport mechanism of drugs by intestinal transporters in the intestine. The purposes of this article are to introduce the main transporters in the intestinal tract, to explain the transport mechanism and to summarize the advantages and disadvantages of the research methods of them.
