Multidrug resistance-associated proteins and their roles in multidrug resistance.
- Author:
Hui ZHANG
1
;
Li-wu FU
Author Information
1. State Key Laboratory of Oncology in South China, Cancer Center Sun Yat-sen University, Guangzhou 510060, China.
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents;
pharmacology;
Drug Resistance, Multiple;
Drug Resistance, Neoplasm;
Humans;
Multidrug Resistance-Associated Proteins;
antagonists & inhibitors;
chemistry;
metabolism;
physiology;
Neoplasms;
drug therapy;
metabolism
- From:
Acta Pharmaceutica Sinica
2011;46(5):479-486
- CountryChina
- Language:Chinese
-
Abstract:
Multidrug resistance (MDR) is a major impediment to the success of cancer chemotherapy. Multidrug resistance-associated proteins (MRPs) play an important role in the process of MDR. As an ATP-binding cassette (ABC) transporter superfamily, MRPs are selective and specific drug efflux pumps. In this paper, physiological characteristics, structural characteristics and resistance profile of MRPs and the associated reversal studies are reviewed.
