Development of targeting thermosensitive liposomes for tumor treatment.
- Author:
Jun CHEN
1
Author Information
1. Department of Pharmaceutics, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China. chenjun75@163.com
- Publication Type:Journal Article
- MeSH:
Animals;
Antineoplastic Agents;
administration & dosage;
therapeutic use;
Drug Carriers;
Drug Delivery Systems;
Humans;
Hyperthermia, Induced;
Liposomes;
administration & dosage;
Neoplasms;
drug therapy
- From:
Acta Pharmaceutica Sinica
2011;46(5):502-506
- CountryChina
- Language:Chinese
-
Abstract:
Liposomes which offer the advantage of the enhanced drug accumulation at tumor sites are currently applied extensively in the clinical treatment of tumor. However, accumulation of the liposomes in the tumor area cannot guarantee the drug bioavailability. To resolve the question, thermosensitive targeting liposomes (TTL) have been the hotspot of current studies. TTL can enhance drug accumulation at tumor sites and be triggered to release their contents upon hyperthermia. By applying these two strategies, antitumor efficacy of encapsulated drug can be significantly improved. The present paper reviews the development of TTL in recent years.
