A new monacolin analogue from Xuezhikang capsule.
- Author:
Xue-mei LI
1
;
Xing-hai SHEN
;
Zhen-wen DUAN
;
Shu-ren GUO
Author Information
1. College of Chemistry and Molecular Engineering, Peking University, Bei4ing 100871, China.
- Publication Type:Journal Article
- MeSH:
Drugs, Chinese Herbal;
chemistry;
Molecular Structure;
Naphthalenes;
chemistry;
isolation & purification;
Propionates;
chemistry;
isolation & purification
- From:
Acta Pharmaceutica Sinica
2011;46(5):564-567
- CountryChina
- Language:English
-
Abstract:
Xuezhikang capsule (ethanol extract of red yeast rice) which produced by Beijing WBL Peking University Biotech Co., Ltd., is a traditional Chinese medication with 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibiting activity. Clinical trials indicated that Xuezhikang with lipid-lowering action could reduce the risk of cardiac events and total mortality of Chinese coronary heart disease patients. To exactly explain the clinical features of Xuezhikang, we undertook a complete study of the chemical constituents of Xuezhikang. This study resulted in the isolation of a new monacolin analogue, named alpha, beta-dehydromonacolin L (1), along with two known compounds: monacolin L (2) and 3-(2, 6-dimethyl-1, 2, 4a, 5, 6, 7, 8, 8a-octahydronaphthalen-1-yl)propanoic acid (3). The chemical structures were determined by extensive 1D and 2D NMR and MS spectroscopic analysis.
