Research progress of new antibacterial drugs that target bacterial quorum sensing systems.
- Author:
Shou-Liang YIN
1
;
Ya-Jing CHANG
;
Su-Ping DENG
;
Qing-Chi WANG
;
Wen-Gong YU
;
Qian-Hong GONG
Author Information
1. Key Laboratory of Marine Drugs, Ministry of Education, College of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Anti-Bacterial Agents;
pharmacology;
therapeutic use;
Bacterial Infections;
drug therapy;
Disease Models, Animal;
Drug Resistance, Bacterial;
Drugs, Chinese Herbal;
pharmacology;
Humans;
Pseudomonas aeruginosa;
drug effects;
pathogenicity;
physiology;
Quorum Sensing;
drug effects;
physiology;
Virulence;
drug effects;
Virulence Factors;
metabolism
- From:
Acta Pharmaceutica Sinica
2011;46(6):613-621
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, antibiotic resistance of bacteria has become a global health crisis. Especially, the new class of "superbug" was found in South Asia, which is resistant to almost known antibiotics and causes worldwide alarm. Through the underlying mechanisms of bacterial pathogenecity, the expression of many pathogen virulence factors is regulated by the process of quorum sensing. Screening efficient quorum sensing inhibitors is an especially compelling approach to the future treatment of bacterial infections and antibiotic resistance. This article focuses on bacterial quorum sensing system, quorum sensing screening model for in vitro and evaluation of animal models in vivo, recent research of quorum sensing inhibitors and so on.
