Advances in the structure-activity relationship study of natural flavonoids and its derivatives.
- Author:
Jian-Qing ZHONG
1
;
Bo LI
;
Qi JIA
;
Yi-Ming LI
;
Wei-Liang ZHU
;
Kai-Xian CHEN
Author Information
1. College of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Anti-Bacterial Agents;
chemistry;
pharmacology;
Anti-Inflammatory Agents;
chemistry;
pharmacology;
Antineoplastic Agents;
chemistry;
pharmacology;
Antioxidants;
chemistry;
pharmacology;
Antisepsis;
Antiviral Agents;
chemistry;
pharmacology;
Fibrinolytic Agents;
chemistry;
pharmacology;
Flavonoids;
chemistry;
isolation & purification;
pharmacology;
Humans;
Plants, Medicinal;
chemistry;
Structure-Activity Relationship;
Vasodilator Agents;
chemistry;
pharmacology
- From:
Acta Pharmaceutica Sinica
2011;46(6):622-630
- CountryChina
- Language:Chinese
-
Abstract:
Flavonoids are a large class of compounds widely distributed in nature. Many pharmacological activities of flavonoids have been reported such as anti-cancer, antioxidant, anti-inflammatory, hepatoprotective, antithrombotic, vasodilator, antiviral, antibacterial, antiallergic, and so on. In recent years, domestic and foreign research groups choose natural flavonoids and optimize their chemical structures in order to develop a number of new derivatives with stronger pharmacological activities. As part of the mechanisms are not clear, we need to strengthen in-depth research in the SAR (structure-activity relationship) study for targeted and efficient structure optimization. This paper systematically summarize current researches in the SAR studies of flavonoids and their derivatives, which can serve as a reference for synthesizing new flavonoid derivatives.
