Tissue distribution of arsenic of liushen pills and realgar.
- Author:
Qing-Li ZHANG
1
;
Qian WU
;
Yuan-Yuan XIE
;
Lian-Zhong SHEN
;
Min-Wei FAN
;
Qiong-Lin LIANG
;
Yi-Ming WANG
;
Guo-An LUO
Author Information
1. Analysis Center, Department of Chemistry, Tsinghua University, Beijing 100084, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Arsenic;
pharmacokinetics;
Arsenicals;
pharmacokinetics;
Chromatography, High Pressure Liquid;
Dogs;
Drug Combinations;
Drugs, Chinese Herbal;
pharmacokinetics;
toxicity;
Female;
Male;
Mass Spectrometry;
Random Allocation;
Sulfides;
pharmacokinetics;
toxicity;
Tissue Distribution
- From:
Acta Pharmaceutica Sinica
2011;46(6):701-706
- CountryChina
- Language:Chinese
-
Abstract:
This study is to report the tissue distribution of arsenic after giving different doses of realgar and Liushen pills to Beagle dogs, in order to provide basis for the safety evaluation of Liushen pills. ICP-MS was used to measure arsenic concentration, and HPLC-ICP-MS was used to analyze arsenic speciation. The concentration of total arsenic and As(III) + DMA (arsenite + dimethylarsenic acid) increased with dosing of realgar. Total arsenic concentration in most tissues and As(III) + DMA concentration in all tissues of Liushen pills group are lower than that of realgar group, but AsB concentration in liver, spleen and kidney of Liushen pills group increased. The concentration of total arsenic showed a dose-dependent manner with dosage administered. It was indicated that components in Liushen pills can reduce solubility of arsenic in realgar, which may decrease toxicity of realgar.
