Thermosensitive in situ gel of boanmycin hydrochloride for injection.
- Author:
Wei-Ming DING
1
;
Mei LI
;
Gui-Ling LI
;
Hong-Zhang XU
;
Ru-Xian CHEN
Author Information
1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Antibiotics, Antineoplastic;
administration & dosage;
pharmacokinetics;
Bleomycin;
administration & dosage;
analogs & derivatives;
pharmacokinetics;
Diffusion;
Drug Delivery Systems;
Gels;
Hypromellose Derivatives;
Injections, Subcutaneous;
Male;
Methylcellulose;
analogs & derivatives;
chemistry;
Microscopy, Electron, Scanning;
Poloxamer;
chemistry;
Rats;
Rats, Sprague-Dawley;
Rheology;
Temperature;
Viscosity
- From:
Acta Pharmaceutica Sinica
2011;46(6):727-732
- CountryChina
- Language:Chinese
-
Abstract:
Poloxamer F127, poloxamer F68 and hydroxypropyl methylcellulose K4M were used to prepare the thermosensitive in situ gel of boanmycin hydrochloride for injection. Its gelation temperature, rheological behavior, texture characteristics, scanning electron microscopy, in vitro and in vivo drug release were evaluated. These results showed that the formulation was a fluid solution at room temperature, which could become semisolid at the temperature of 37 degrees C, and the thermally induced sol-gel transition allowed to be injectable and in situ setting. The formulation was constructed into a tridimensional network at gelation temperature. The drug release was controlled by the diffusion of the drug and the erosion of the gelmatrix. The pharmacokinetics indicated that the drug could be released slowly for up to 48 hours after subcutaneous administration in rats.
