Study on the clinical use of alpha-fetoprotein (AFP) colloidal gold diagnostic strip.
- Author:
Xian-min JIANG
1
;
Jian KONG
;
Tao LIN
;
Xiu-ying YU
;
Ying CHEN
;
Yu DAI
;
Hang-yan YANG
;
Xiao-li SUN
;
Jian YANG
;
Yong-quan YANG
;
Yan-chun ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Biomarkers, Tumor; blood; Carcinoma, Hepatocellular; diagnosis; Double-Blind Method; Gold Colloid; Humans; Liver Neoplasms; diagnosis; Radioimmunoassay; Reagent Kits, Diagnostic; Reproducibility of Results; Sensitivity and Specificity; alpha-Fetoproteins; analysis
- From: Chinese Journal of Epidemiology 2003;24(3):210-212
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo test the sensitivity and specificity of alpha-fetoprotein (AFP) colloidal gold diagnostic strip as compared with RIA-AFP diagnostic kit.
METHODSDouble blind method was used to test sera from 426 healthy people and 1567 patients selected in two general hospitals and a cancer hospital. Each serum was measured by RIA-AFP and AFP colloidal gold diagnostic strip on the same day. RIA-AFP diagnostic results was identified as true positive or negative.
RESULTSAmong 426 healthy people, all the RIA-AFP test showed negative result (serum AFP concentration less than 25 IU/ml), but the AFP colloidal gold diagnostic strip had 1.88% false positive. When comparing the result from 1567 patients measured by RIA-AFP, the sensitivity and specificity of AFP colloidal gold diagnostic strip were 99.3%, and 97.2%, respectively. The crude correspondence rate between the two diagnostic regents was 97.6%.
CONCLUSIONAFP colloidal gold diagnostic strip showed very good result and could be used as a screening diagnostic kit in clinic and hospital settings.
