A case-control study on the vitamin D receptor gene polymorphisms and susceptibility to pulmonary tuberculosis.
- Author:
Wei LIU
1
;
Cui-ying ZHANG
;
Xiao-ming WU
;
Lei TIAN
;
Chun-zhi LI
;
Qiu-min ZHAO
;
Pan-he ZHANG
;
Shu-mei YANG
;
Hong YANG
;
Xi-tan ZHANG
;
Wu-chun CAO
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Case-Control Studies; Child; Genetic Predisposition to Disease; genetics; Genotype; Humans; Logistic Models; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Receptors, Calcitriol; genetics; Tuberculosis, Pulmonary; genetics
- From:Chinese Journal of Epidemiology 2003;24(5):389-392
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between the genetic polymorphisms of VDR gene and susceptibility to pulmonary tuberculosis.
METHODSCase-control study was conducted. PCR-RFLP technique was used to detect the C/T polymorphism in VDR gene. Information on related factors of tuberculosis was collected using a pre-tested questionnaire. Univariate and multivariate logistic analyses were conducted with SPSS software package.
RESULTSA sample of 76 cases and 171 controls was studied. The genotype frequencies of VDR-FF, VDR-Ff and VDR-ff were 38.2%, 44.7%, 17.1% and 52.6%, 40.9%, 6.4% respectively. VDR-ff was significantly overrepresented in case group, the OR (95% CI) was 3.668 (1.483 - 9.071) when comparing with FF genotype. The significant association remained after adjusting BCG immunization and smoking, the OR (95% CI) was 3.036 (1.117 - 8.253).
CONCLUSIONThe VDR-ff genotype might be associated with the susceptibility to pulmonary tuberculosis in Chinese Han population.
