Pathological studies of tissue damage in experimental rabbit liver cancer induced by energy controllable steep pulses.
- Author:
Ping-ling WANG
1
;
Li-na HU
;
Xiao-jun YANG
;
Jun LI
;
Cai-xin SUN
;
Lan XIONG
;
Chen-guo YAO
;
Shi-bin WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Electric Conductivity; Electromagnetic Fields; Electroporation; methods; Female; Liver Neoplasms, Experimental; pathology; Male; Rabbits
- From: Chinese Journal of Hepatology 2005;13(7):516-519
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the efficacy of energy controllable steep pulses (ECSP) in the treatment of rabbit VX2 cancer implanted in livers.
METHODSA tumor model was successfully established using 30 rabbits. ECSP were applied to liver cancer in half of these rabbits and the rest were used as controls. After exposure to ECSP, tissues were obtained and subjected by routine HE and transmission electron microscopic (TEM) observation. The survival time of the animals and the statuses of each group were recorded.
RESULTSFrom pathological observations, ECSP showed effectively destructive action compared with that of the unexposed group. A clear borderline can be seen between necrotic cancer and its surrounding normal tissue. Irreversible cell changes were present under TEM. The survival periods of the experimental and control group were 83.1 days and 39.0 days respectively, and there was a significant difference between the two groups (Z = -2.943, P < 0.01).
CONCLUSIONECSP can effectively treat rabbit VX2 cancer implanted in the liver; also it is safe for its surrounding normal tissues. ECSP can be a useful method for local treatment of liver cancer.
