A study about the association of detoxication gene GSTM1 polymorphism and the susceptibility to aflatoxin B1-related hepatocellular carcinoma.
- Author:
Xi-dai LONG
1
;
Yun MA
;
Yi-ping WEI
;
Zhuo-lin DENG
Author Information
- Publication Type:Journal Article
- MeSH: Aflatoxin B1; genetics; Carcinoma, Hepatocellular; genetics; Genetic Predisposition to Disease; Glutathione Transferase; genetics; Humans; Liver Neoplasms; genetics; Polymorphism, Genetic
- From: Chinese Journal of Hepatology 2005;13(9):668-670
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVESTo investigate the association between susceptibility to aflatoxin B1(AFB1)-related hepatocellular carcinoma (HCC) and the polymorphism of detoxication gene GSTM1.
METHODSThe peripheral white blood cell DNA samples were obtained from all the subjects including 140 HCC cases and 536 controls from an AFB1 high risk area in Guangxi province. The GSTM1 polymorphism was detected using PCR technique.
RESULTS(1) The GSTM1-present was associated with a decreased HCC risk. The GSTM1-null was associated with an increased HCC risk [adjusted OR (95% CI)= 2.07 (1.20-3.57)]. (2) In the cohorts of both low/median and high exposure levels of AFB1, GSTM1-null genotype was associated with a conspicuous significantly increased risk for HCC [adjusted OR (95% CI) = 1.92 (0.92-4.00) and 1.80 (0.77-4.17)].
CONCLUSIONThe results suggest that genetic polymorphism of GSTM1 was susceptible to HCC and individuals who are GSTM1-null have an increased risk of developing HCC. There is evidence of interaction between GSTM1 polymorphism and AFB1 exposure, especially with low/median degrees of AFB1 exposure.
