Effects of folate deficiency with HPV16 infection on cervix cancerization
10.3760/cma.j.issn.0254-6450.2014.04.021
- VernacularTitle:叶酸缺乏及其与HPV16感染的交互效应对宫颈癌变的影响
- Author:
Xuesong SUN
1
;
Ling DING
;
Fang CHEN
;
Tingting WU
;
Jintao WANG
Author Information
1. 山西医科大学公共卫生学院流行病学教研室
- Keywords:
Serum folate;
RBC folate;
HPV16;
Cervix cancerization
- From:Chinese Journal of Epidemiology
2014;35(4):437-441
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between folate in serum,red blood cell (RBC),cervix cancerization,as well as the interaction between folate deficiency and HPV16 infection in cervix cancerization.Methods 254 samples were selected from the patients who were newly pathologically diagnosed of having cervix inflammation (CI),low-grade cervical intraepithelial neoplasia (CIN Ⅰ),high-grade cervical intraepithelial neoplasia (CIN Ⅱ/Ⅲ) and cervical squamous cell carcinoma (SCC).PCR and microbiological assay were adopted to detect HPV infection and folate concentration.Results Rates of HPV16 infection increased with the severity of cervix cancerization (tend:x2=34.96,P＜0.001),while decreased with concentrations of serum and RBC folate (tend:x2=42.17,P＜0.001; tend:x2=31.39,P＜0.001).There was a positive correlation between serum and RBC folate (r=0.405,P＜0.001).Data from grouping analysis showed that OR and aOR of serum and RBC folate appeared a rising trend,with statistical significance in CIN Ⅱ/Ⅲand SCC,but did not show the same trend in CIN Ⅰ.Results from interaction analysis showed that serum folate deficiency had an additive interaction with HPV16 infection in CIN Ⅱ/Ⅲ and SCC,while RBC folate having an additive interaction with HPV16 infection in the whole process of cervix cancerization.Conclusion Both serum and RBC folate deficiency could increase the risk of cervix cancerization,and folate deficiency might have a synergic action with HPV 16 in this procession.
