Association between pancreatic cancer risk and the interaction of U2AF65 gene polymorphisms and smoking.

Jing Tian; Beibei Zhu; Yao Tian; Rong Zhong; Xiaoping Miao; Li Wang

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Association between pancreatic cancer risk and the interaction of U2AF65 gene polymorphisms and smoking.

Author: Jing TIAN ¹ ; Beibei ZHU ² ; Yao TIAN ¹ ; Rong ZHONG ² ; Xiaoping MIAO ³ ; Li WANG ⁴
Author Information

1. Department of Epidemiology and Biostatistics,Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College,Beijing 100005, China.
2. Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology.
3. Email: miaoxp@gmail.com.
4. Department of Epidemiology and Biostatistics,Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College,Beijing 100005, China. Email: liwang@ibms.pumc.edu.cn.
Publication Type:Journal Article
MeSH: Aged; Case-Control Studies; Female; Genotype; Humans; Male; Middle Aged; Nuclear Proteins; genetics; Pancreatic Neoplasms; genetics; Polymorphism, Single Nucleotide; Ribonucleoproteins; genetics; Risk Factors; Smoking; Splicing Factor U2AF
From: Chinese Journal of Epidemiology 2014;35(6):710-713
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo determine the association between U2 small nuclear ribonucleoprotein auxiliary factor 35/65 (U2AF35 and U2AF65) and pancreatic cancer (PC).
METHODSA two-stage analysis case-control study was conducted. Four candidate tag single nucleotide polymorphisms (tagSNPs) were genotyped by Taqman Openarray assay in a screening population living in Central China (298 PC cases and 525 controls). Thereafter, rs310445 in U2AF65 was genotyped by TaqMan real-time polymerase chain reaction (RT-PCR) in a validation Chinese Han population from Beijing (413 cases and 557 controls).
RESULTSrs310445 in U2AF65 gene was significantly associated with PC in both screened population and combined population. Subjects with C allele had a higher risk of PC compared to those with the TT genotype, with OR of 1.31 (95%CI:1.07-1.60, P = 0.010) for the combined population. A synergic effect of smoking and C allele of rs310445 was also observed in the combined population, with Synergic Index of 2.08 (95% CI:1.37-2.78) in the combined population.
CONCLUSIONOur findings suggested the interaction between smoking and U2AF65 might play a role in PC. These findings should be confirmed by further independently large-scale population studies.