Genetic subtype and epidemiological feature of HIV-1 circulating strains among recently infected patients in Fujian province.

Yongyue Deng; Chunyang Zhang; Yansheng Yan; Pingping Yan; Shouli WU

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Genetic subtype and epidemiological feature of HIV-1 circulating strains among recently infected patients in Fujian province.

Author: Yongyue DENG ^{1
,

2} ; Chunyang ZHANG ³ ; Yansheng YAN ⁴ ; Pingping YAN ³ ; Shouli WU ³
Author Information

1. Affiliated Zhongshan Hospital of Xiamen University, Xiamen 361004, China
2. School of Public Health, Fujian Medical University.
3. Fujian Provincial Center for Disease Control and Prevention.
4. Fujian Provincial Center for Disease Control and Prevention. Email: yysh@fjcdc.com.cn.
Publication Type:Journal Article
MeSH: Adult; China; epidemiology; Female; Genotype; HIV Infections; epidemiology; HIV-1; classification; genetics; Humans; Male; Molecular Epidemiology; Young Adult
From: Chinese Journal of Epidemiology 2014;35(6):714-719
CountryChina
Language:Chinese
Abstract:
OBJECTIVEIn order to evaluate the distribution of genetic subtypes and epidemiological feature of HIV-1 circulating strains in Fujian province.
METHODSBlood samples and epidemiological data were collected from 104 newly infected patients who were distinguished by BED-CEIA methodology, during 2011-2012. Viral sequences(n = 81) of HIV-1 gag, env, and pol segments were amplified by nested PCR.
RESULTSSubtypes B and four Circulating Recombinant Forms, (CRF01_AE, CRF07_BC, CRF08_BC and CRF55_01B) were found in the samples, CRF01_AE(45.68%)and CRF07_BC(35.80%) were the two main HIV-1 strains in Fujian province. Compared with previous data, the proportion of CRF07_BC rose significantly while it gradually decreased in CRF01_AE. Heterosexual contact was still the principal transmission route in Fujian province, but the number of infection among men-who-have-sex-with- men grew rapidly.
CONCLUSIONResults from this study suggested that different subtypes of HIV-1 strain existed in Fujian province. The distribution of subtypes and the mode of transmission were changing with the progress of epidemic. Dynamic monitoring of the molecular epidemiology trends of HIV-1 infection should be enhanced.